Oxidative stress Assay Kits

Oxidative stress refers to an imbalance between the production of reactive oxygen species (ROS) and the cell’s ability to neutralize or eliminate them through antioxidant defenses. Under normal physiological conditions, cells maintain a reduced intracellular environment essential for preserving the integrity of macromolecules and supporting cellular functions. However, when ROS such as hydrogen peroxide (H₂O₂), superoxide anions (O₂⁻), hydroxyl radicals (•OH), and other free radicals accumulate excessively—often triggered by environmental factors, metabolic dysfunction, or inflammation—they disrupt this balance. These reactive species can inflict severe damage on cellular components, including DNA, lipids, proteins, and enzyme cofactors. Such oxidative modifications can alter gene expression, compromise membrane integrity, and impair enzymatic activities. If the oxidative damage overwhelms repair mechanisms, it may lead to programmed cell death (apoptosis) or uncontrolled cell lysis (necrosis), contributing to tissue injury and the progression of various diseases, including cancer, neurodegeneration, and cardiovascular disorders.

To counteract oxidative stress, cells rely on a network of antioxidant enzymes such as catalase, superoxide dismutase (SOD), glutathione peroxidase, and lactoperoxidase. These enzymes act to neutralize ROS and maintain redox homeostasis. To support researchers in evaluating oxidative damage and antioxidant defense systems, we offer sensitive and reliable assay kits specifically designed to measure oxidative stress markers in biological samples.