Human plasma is the liquid fraction of anticoagulated blood and contains a complex mixture of proteins, peptides, lipids, metabolites, extracellular vesicles, cell-free nucleic acids, and other circulating molecules. Its molecular composition can reflect physiological and pathological processes, making human plasma an important biospecimen for biomarker research, plasma proteomics, metabolomics, immunology, oncology, cardiovascular research, and translational studies.
Key Features
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Complex source of circulating proteins, peptides, metabolites, lipids, extracellular vesicles, and cell-free nucleic acids.
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Suitable for proteomic, metabolomic, lipidomic, immunological, and biomarker analyses.
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Supports comparative molecular profiling across health and disease states.
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Suitable for biobanking, retrospective analyses, and longitudinal research.
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Pre-analytical factors, including collection tube and anticoagulant, processing time and temperature, centrifugation, storage conditions, hemolysis, and freeze–thaw history—can influence downstream measurements and should be documented and standardized.
Typical Research Applications
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Biomarker discovery and validation.
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Plasma proteomics and peptidomics.
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Metabolomics and lipidomics.
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Mass spectrometry-based molecular profiling.
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Immunoassays and protein quantification.
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Cancer and cardiovascular research.
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Disease-associated molecular profiling and translational research.
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Precision medicine and longitudinal studies.