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Wnt pathway inhibitor 3 [663213-98-7]

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Cat# NB-64-42469-10mg

Size : 10mg

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Wnt pathway inhibitor 3

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Synonyms:

Catalog No. T77502 Copy Product Info

Purity: 99.94%

Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.

Cas No. 663213-98-7

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.
Targets & IC50	AC type I:45 nM
In vitro	Wnt pathway inhibitor 3 (compound 41) (0-100 μM; 72 h) exhibited anti-proliferative activity with IC50 values of 641, 470, 551, and 618 nM for HS68, Dld1, HCT116, and SW480 cells, respectively.[1]

Chemical Properties

Molecular Weight	457.27
Formula	C₂₁H₁₇BrN₂O₅
Cas No.	663213-98-7
Smiles	C(#N)C=1C(C2=C(C=C3C(=C2)OCO3)OC1N)C4=CC(OC)=C(OCC=C)C(Br)=C4
Relative Density.	1.59 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (131.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1869 mL	10.9345 mL	21.8689 mL	109.3446 mL
5 mM	0.4374 mL	2.1869 mL	4.3738 mL	21.8689 mL
10 mM	0.2187 mL	1.0934 mL	2.1869 mL	10.9345 mL
20 mM	0.1093 mL	0.5467 mL	1.0934 mL	5.4672 mL
50 mM	0.0437 mL	0.2187 mL	0.4374 mL	2.1869 mL
100 mM	0.0219 mL	0.1093 mL	0.2187 mL	1.0934 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

βcateninWntpathwayinhibitor3Wnt/β-cateninWnt/betacateninWnt/b-cateninWnt pathway inhibitor 3Wntbeta-cateninbetacateninbcateninAdenylylcyclaseadenylyl cyclase 1(AC1)Adenylyl cyclase

Related Tags: Wnt pathway inhibitor 3 chemical structure | Wnt pathway inhibitor 3 in vitro | Wnt pathway inhibitor 3 formula | Wnt pathway inhibitor 3 molecular weight