Rat ATP2B2 (ATPase, Ca++ Transporting, Plasma Membrane 2) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Atp2b2
Gene ID:	24215
Uniprot ID:	AT2B2_RAT
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Isoforms containing segment B are found in brain, uterus, liver and kidney and in low levels in other tissues. Isoforms containing segment W are found in kidney, uterus, and pancreas. Isoforms containing segment Y are found in pancreas and in low levels in brain and heart. Isoforms containing segment Z are found in brain and heart and isoforms containing segment X are found in low levels in brain. Isoforms containing segment A are found in low levels in heart and small intestine while isoforms containing segment C are found in testis and in low levels in other tissues.
Post Translational Modifications
Function	ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
Protein Name	Plasma Membrane Calcium-Transporting Atpase 2 Pmca2 Plasma Membrane Calcium Atpase Isoform 2 Plasma Membrane Calcium Pump Isoform 2
Database Links	Reactome: R-RNO-418359 P11506-2 Reactome: -RNO-5578775 P11506-2 Reactome: -RNO-936837 P11506-2
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Synapse Apical Cell Membrane Basolateral Cell Membrane
Alternative ELISA Names	Plasma Membrane Calcium-Transporting Atpase 2 ELISA kit Pmca2 ELISA kit Plasma Membrane Calcium Atpase Isoform 2 ELISA kit Plasma Membrane Calcium Pump Isoform 2 ELISA kit Atp2b2 ELISA kit
output

Information sourced from Uniprot.org

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