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Quinacrine analog 34 [1411646-44-0]

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Cat# NB-64-23426-1mg

Size : 1mg

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Quinacrine analog 34

(Synonyms: Autophagy-IN-4) Copy Product Info

Synonyms: Autophagy-IN-4

Catalog No. T35747 Copy Product Info

Purity: 99.98%

Quinacrine analog 34 is a potent autophagy inhibitor (EC₅₀ = 0.5 μM, LD₅₀ = 27 μM) that upregulates the protein levels of the autophagy marker LC3-II and induces lysosomal deacidification.

Cas No. 1411646-44-0

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Quinacrine analog 34 is a potent autophagy inhibitor (EC₅₀ = 0.5 μM, LD₅₀ = 27 μM) that upregulates the protein levels of the autophagy marker LC3-II and induces lysosomal deacidification.
Targets & IC50	autophagy:2.5 μM (LD₅₀)
Synonyms	Autophagy-IN-4

Chemical Properties

Molecular Weight	358.91
Formula	C₂₀H₂₇ClN₄
Cas No.	1411646-44-0
Smiles	ClC=1C=CC2=C(N=C3C(=C2NCCN4CCN(C)CC4)CCCC3)C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (13.93 mM), Sonication is recommended.

DMSO:PBS (pH 7.2) (1:1): < 1?mg/mL?(insoluble), Sonication is recommended.

Ethanol: 2.5 mg/mL (6.97 mM), Sonication is recommended.

DMF: 5 mg/mL (13.93 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	2.7862 mL	13.9311 mL	27.8621 mL	139.3107 mL
5 mM	0.5572 mL	2.7862 mL	5.5724 mL	27.8621 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
10 mM	0.2786 mL	1.3931 mL	2.7862 mL	13.9311 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Related Tags: Quinacrine analog 34 chemical structure | Quinacrine analog 34 formula | Quinacrine analog 34 molecular weight