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> Notch 3 Protein, Human, Recombinant (His & Avi)

Notch 3 Protein, Human, Recombinant (His & Avi)

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Cat# NB-64-55046-10ug

Size : 10ug

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Notch 3 Protein, Human, Recombinant (His & Avi)

(Synonyms: Notch-3, NOTCH3, Notch homolog 3, CADASIL) Copy Product Info

Synonyms: Notch-3, NOTCH3, Notch homolog 3, CADASIL

Catalog No. TMPK-01360 Copy Product Info
Notch 3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is Q9UM47.
Other Forms of Notch 3 Protein, Human, Recombinant (His & Avi):
Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Notch 3 Protein, Human, Recombinant (hFc)
Notch 3 Protein, Human, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Notch 3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is Q9UM47.
Species
Human
Expression System
HEK293 Cells
TagC-His-Avi
Accession NumberQ9UM47
ConstructionAla40-Glu467
Protein Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsNotch-3, NOTCH3, Notch homolog 3, CADASIL
Research Background
Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
Chemical Properties
Molecular Weight47.7 kDa (predicted). Due to glycosylation, the protein migrates to 53-60 kDa based on Tris-Bis PAGE result.
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

NOTCH-3NOTCH 3
Related Tags: Notch 3 Protein, Human, Recombinant (His & Avi) chemical structure | Notch 3 Protein, Human, Recombinant (His & Avi) molecular weight