Inetetamab
Cat# NB-64-82311-5mg
Size : 5mg
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Inetetamab
Catalog No. T78335 Copy Product Info
Inetetamab is a humanized monoclonal antibody targeting HER2 receptor domain IV, exhibiting antitumor activity through inducing pyroptosis in lung adenocarcinoma. It is used in studies of HER2-positive metastatic breast cancer.
Inetetamab
Copy Product InfoInetetamab is a humanized monoclonal antibody targeting HER2 receptor domain IV, exhibiting antitumor activity through inducing pyroptosis in lung adenocarcinoma. It is used in studies of HER2-positive metastatic breast cancer.
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Purity:96.54% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Inetetamab is a humanized monoclonal antibody targeting HER2 receptor domain IV, exhibiting antitumor activity through inducing pyroptosis in lung adenocarcinoma. It is used in studies of HER2-positive metastatic breast cancer. |
| In vitro | Inetetamab is a novel anti-HER2 monoclonal antibody. In combination with cisplatin, inetetamab increases ROS levels by inhibiting HER2/AKT/Nrf2 signaling, thereby triggering NLRP3/caspase-1/GSDMB mediated pyroptosis. Synergistically enhance the anti-tumor efficacy of LUAD cells. [1] |
| In vivo | Inetetamab (20 mg/kg intraperitoneally injected) showed antitumor effects in JIMT-1 xenograft mouse models. Inetetamab (20 mg/kg intraperitoneally injected) in combination with Pyrotinib or Cyclophosphamide demonstrated significant antitumor effects in JIMT-1 and NCI-N87 xenograft mouse models. [2] |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB2/HER2/CD340 |
| Molecular Weight | 145.1 kDa |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |