Reagents and instruments for immunology, cell biology and molecular biology.

EGTA [67-42-5]

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Cat# NB-64-28845-5g

Size : 5g

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EGTA

(Synonyms: Ethylenebis(oxyethylenenitrilo)tetraacet) Copy Product Info

Synonyms: Ethylenebis(oxyethylenenitrilo)tetraacet

Catalog No. T4585 Copy Product Info

Purity: 99.92%

Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.

Cas No. 67-42-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.92%

Appearance:Solid

Color:White

Product Information

EGTA AI Summary

EGTA exhibits multi-faceted biological activities. It significantly inhibits the invasion of Plasmodium falciparum FCB2 merozoites into human erythrocytes, showing an inhibition rate of 83.0% at a concentration of 50 mM and 90.0% at 1.9 mg/mL after 18 hours. Additionally, it demonstrates a substantial inhibition of aph8 phosphorylation in Streptomyces coelicolor cell lysate, achieving a 94.0% inhibition as assessed by [32Pi] incorporation. Moreover, compound 405836 is involved in inhibiting various enzymes and biological processes, including APE1, fructose-1,6-bisphosphate aldolase, Bloom's syndrome helicase BLM, HADH2, and histone lysine methyltransferase G9a. It also modulates PMP22 expression/activity, acts as an allosteric agonist for the human D1 dopamine receptor, and inhibits cell entry of Lassa and Marburg viruses. Additionally, it enhances Arylsulfatase A and activates the ryanodine receptor in Spodoptera litura muscle membrane, inducing a Ca2+ pump activity at 0.8 mM after 30 minutes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Synonyms	Ethylenebis(oxyethylenenitrilo)tetraacet

Chemical Properties

Molecular Weight	380.35
Formula	C₁₄H₂₄N₂O₁₀
Cas No.	67-42-5
Smiles	OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O
Relative Density.	1.433 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M NaOH: 25 mg/mL (65.73 mM), Sonication is recommended.

DMSO: Insoluble

H2O: < 1 mg/mL (insoluble)

Solution Preparation Table

0.1 M NaOH

	1mg	5mg	10mg	50mg
1 mM	2.6292 mL	13.1458 mL	26.2916 mL	131.4579 mL
5 mM	0.5258 mL	2.6292 mL	5.2583 mL	26.2916 mL
10 mM	0.2629 mL	1.3146 mL	2.6292 mL	13.1458 mL
20 mM	0.1315 mL	0.6573 mL	1.3146 mL	6.5729 mL
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6292 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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