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Miconazole [22916-47-8]

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Referentie NB-64-00509-500mg

Formaat : 500mg

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Miconazole

(Synonyms: R18134) Copy Product Info

Synonyms: R18134

Catalog No. T0344 Copy Product Info

Purity: 99.89%

Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion.

Cas No. 22916-47-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Color:White

Product Introduction

Miconazole AI Summary

Miconazole exhibits potent antifungal activity against a variety of fungal pathogens, particularly against Candida species and dermatophytes. It shows high efficacy with low minimum inhibitory concentrations (MIC) ranging from 0.156 to 25.0 ug/mL, indicating strong inhibitory effects against Candida albicans, Aspergillus fumigatus, Trichophyton mentagrophytes, and others. Additionally, Miconazole demonstrates fungicidal activity with MIC values often below 0.78 ug/mL for some dermatophytes like Microsporum canis and Trichophyton asteroides. In in vivo studies, Miconazole significantly inhibits fungal infections in animal models such as guinea pigs and hamsters, reducing lesion scores and fungal culture positivity. It enhances the activity of enzymes like styrene oxide hydrolase and epoxide hydrolase, indicated by specific enhancement metrics and partition coefficients like LogP (5.84). The compound is also an effective inhibitor of Cytochrome P450 enzymes, particularly CYP51, and shows inhibitory activity against Cytochrome P450 3A4 with relevant IC50 values, contributing to its wide spectrum of bioactivity. Moreover, Miconazole exhibits inhibitory effects on other enzymes and proteins, including beta-lactamase, malate dehydrogenase, and Tdo2. The compound's bioactivity spectrum extends to showing cytotoxicity in human cell lines and specific antimicrobial activity against various bacterial strains, although it demonstrates moderate to low antibacterial efficacy. Overall, Miconazole is a promising antifungal agent with potential applications in treating diverse fungal infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion.
Synonyms	R18134

Chemical Properties

Molecular Weight	416.13
Formula	C₁₈H₁₄Cl₄N₂O
Cas No.	22916-47-8
Smiles	C(CN1C=CN=C1)(OCC2=C(Cl)C=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3
Relative Density.	1.4g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (600.77 mM), Sonication is recommended.

Ethanol: 77 mg/mL (185.04 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn oil: 10 mg/mL (24.03 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (24.03 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% (20% SBE-β-CD in Saline): < 10 mg/mL (24.03 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: < 10 mg/mL (24.03 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4031 mL	12.0155 mL	24.0310 mL	120.1548 mL
5 mM	0.4806 mL	2.4031 mL	4.8062 mL	24.0310 mL
10 mM	0.2403 mL	1.2015 mL	2.4031 mL	12.0155 mL
20 mM	0.1202 mL	0.6008 mL	1.2015 mL	6.0077 mL
50 mM	0.0481 mL	0.2403 mL	0.4806 mL	2.4031 mL
100 mM	0.0240 mL	0.1202 mL	0.2403 mL	1.2015 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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Dilution Calculator
Reconstitution Calculator
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

R-18134R 18134PotassiumChannelPotassium ChannelMiconazoleiNOSInhibitorinhibitFungaleNOSBacterialAntibiotic14-α Demethylase

Related Tags: Miconazole chemical structure | Miconazole formula | Miconazole molecular weight

Miconazole [22916-47-8]

Referentie NB-64-00509-500mg

Neem contact op met een lokale distributeur :

Neem contact op met een lokale distributeur :

Miconazole

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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