Size : 10mg
Phone : +1 850 650 7790
Synonyms:
| Description | CF-Carvacrol is an orally active lipid-lowering agent synthesized by combining Carvacrol and Clofibric acid. It shows strong affinity for PPAR-α and demonstrates significant hypolipidemic activity. Additionally, CF-Carvacrol exerts antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway, thereby alleviating liver damage. This compound is applicable in research on liver injury induced by cystic fibrosis. |
| In vivo | CF-Carvacrol, administered orally at doses of 46.3-185.2 mg/kg (0.1335-0.534 mmol/kg) daily for 7 days, demonstrates a significant dose-dependent lipid-lowering effect in hyperlipidemic Kunming (KM) mice. Furthermore, at a dose of 572.3 g/kg (1.65 mol/kg) given daily for one month, it reduces plasma levels of AST, ALT, and AKP, alleviates oxidative stress and inflammation, and improves liver tissue morphology in KM mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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