Size : 1g
Phone : +1 850 650 7790
Synonyms: Tyrosine, P-Tyrosine, L-p-Tyrosine, (S)-Tyrosine
| Description | L-Tyrosine ((S)-Tyrosine) is a naturally occurring tyrosine and is synthesized in vivo from L-phenylalanine, considered a non-essential amino acid. L-Tyrosine(L-p-Tyrosine) is the levorotatory isomer of the aromatic amino acid tyrosine. |
| In vitro | L-tyrosine in vitro inhibits citrate synthase activity in the posterior cortex. Succinate dehydrogenase activity is increased in the posterior cortex, hippocampus, striatum and liver. Complex I activity is inhibited in the hippocampus, complex II activity is also inhibited in the hippocampus and in the posterior cortex and liver, complex II–III activity is not altered by L-tyrosine and complex IV activity decreased in the posterior cortex[1]. |
| In vivo | Acute administration of L-tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum[1]. |
| Synonyms | Tyrosine, P-Tyrosine, L-p-Tyrosine, (S)-Tyrosine |
| Molecular Weight | 181.19 |
| Formula | C9H11NO3 |
| Cas No. | 60-18-4 |
| Smiles | C([C@@H](C(O)=O)N)C1=CC=C(O)C=C1 |
| Relative Density. | 1.34 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | 0.1 M HCl: 10 mg/mL (55.19 mM), Sonication is recommended.  DMSO: Insoluble H2O: Insoluble | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
0.1 M HCl
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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