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L-Ascorbic acid sodium salt [134-03-2]

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Cat# NB-64-35373-500mg

Size : 500mg

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L-Ascorbic acid sodium salt

(Synonyms: Vitamin C sodium salt, Sodium L-ascorbate, Sodium ascorbate, L-Ascorbic acid sodium, (+)-Sodium L-ascorbate) Copy Product Info

Synonyms: Vitamin C sodium salt, Sodium L-ascorbate, Sodium ascorbate, L-Ascorbic acid sodium, (+)-Sodium L-ascorbate

Catalog No. T6674 Copy Product Info

Purity: 99.75%

L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

Cas No. 134-03-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.75%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
In vitro	Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. [1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. [2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. [3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. [4]
In vivo	Tg rats treated with sodium?L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium?L-ascorbate (15.4%). Independent of the sodium?L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium?L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium?L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].
Synonyms	Vitamin C sodium salt, Sodium L-ascorbate, Sodium ascorbate, L-Ascorbic acid sodium, (+)-Sodium L-ascorbate

Chemical Properties

Molecular Weight	198.11
Formula	C₆H₇NaO₆
Cas No.	134-03-2
Smiles	[O-]C[C@@H]([C@]1(20)C(O)=C(C(O1)=O)O)O.[Na+]
Relative Density.	1.88. Temperature:19.7 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.25 mg/mL (31.55 mM), Sonication is recommended.

H2O: 198.9 mM, Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.0477 mL	25.2385 mL	50.4770 mL	252.3850 mL
5 mM	1.0095 mL	5.0477 mL	10.0954 mL	50.4770 mL
10 mM	0.5048 mL	2.5239 mL	5.0477 mL	25.2385 mL
20 mM	0.2524 mL	1.2619 mL	2.5239 mL	12.6193 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.1010 mL	0.5048 mL	1.0095 mL	5.0477 mL
100 mM	0.0505 mL	0.2524 mL	0.5048 mL	2.5239 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Vitamin C sodiumVitamin CReactiveOxygenSpeciesReactive Oxygen SpeciesLAscorbic acid sodium saltL-Ascorbic acidL Ascorbic acid sodium saltInhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteCalciumChannelCalcium ChannelCa2+ channelsCa channelsApoptosis

Related Tags: L-Ascorbic acid sodium salt chemical structure | L-Ascorbic acid sodium salt in vivo | L-Ascorbic acid sodium salt in vitro | L-Ascorbic acid sodium salt formula | L-Ascorbic acid sodium salt molecular weight