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> Fas Ligand Protein, Human, Recombinant (His)

Fas Ligand Protein, Human, Recombinant (His)

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Cat# NB-64-59018-5ug

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Fas Ligand Protein, Human, Recombinant (His)

(Synonyms: TNLG1A, TNFSF6, FASLG, FASL, Fas ligand, CD95-L, CD95L, CD178, APTL, APT1LG1, ALPS1B) Copy Product Info

Synonyms: TNLG1A, TNFSF6, FASLG, FASL, Fas ligand, CD95-L, CD95L, CD178, APTL, APT1LG1, ALPS1B

Catalog No. TMPY-03956 Copy Product Info
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
Other Forms of Fas Ligand Protein, Human, Recombinant (His):
Fas Ligand Protein, Mouse, Recombinant (His)TMPY-04587
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:89.7%
Appearance:Lyophilized powder
Color:White
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Product Introduction

Bioactivity
Bioactivity
Immobilized Human Fas/CD95 hFc at 2 μg/mL (100 μL/well) can bind Human Fas Ligand His , the EC50 of Human Fas Ligand His is 40-200 ng/mL.
Description
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
Species
Human
Expression System
P. pastoris (Yeast)
TagN-His
Accession NumberP48023-1
ConstructionA DNA sequence encoding human FASLG (NP_000630.1) (Pro134-Leu281) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: His
Protein Purity
> 90 % as determined by SDS-PAGE
Fas Ligand Protein, Human, Recombinant (His)
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionReconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
SynonymsTNLG1A, TNFSF6, FASLG, FASL, Fas ligand, CD95-L, CD95L, CD178, APTL, APT1LG1, ALPS1B
Research Background
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Chemical Properties
Molecular Weight19.3 kDa (predicted); 26 kDa (reducing conditions)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

TNFSF-6TNFSF 6CD-178CD 178
Related Tags: Fas Ligand Protein, Human, Recombinant (His) chemical structure | Fas Ligand Protein, Human, Recombinant (His) molecular weight