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Alternariol [641-38-3]

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Cat# NB-64-05700-2mg

Size : 2mg

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Alternariol

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Synonyms:

Catalog No. T14196 Copy Product Info

Purity: 99.57%

Alternariol is a natural product extracted from Etoac that demonstrates anti-inflammatory activity in vitro and in vivo in murine hepatoma cells and in human serum, with additional effects on toll-like receptor signaling and regulation of pro-apoptotic protein expression. Alternariol has been shown to be inactive against methyl transferase enzymes, a feature relevant to its metabolic inactivation profile.

Cas No. 641-38-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.57%

Appearance:Solid

Color:Yellow

Product Introduction

Bioactivity

Description	Alternariol is a natural product extracted from Etoac that demonstrates anti-inflammatory activity in vitro and in vivo in murine hepatoma cells and in human serum, with additional effects on toll-like receptor signaling and regulation of pro-apoptotic protein expression. Alternariol has been shown to be inactive against methyl transferase enzymes, a feature relevant to its metabolic inactivation profile.
In vitro	Treatment of human lung epithelial cells (BEAS-2B) and mouse macrophages (RAW264.7) with Alternariol (10 μM, 24 h) can inhibit the innate immune response of both cell types [2]. Alternariol (5-10 μM, 24 h) reduces LPS-induced inflammatory response in BEAS-2B cells in a dose-dependent manner [2]. Alternariol (1-100 μM, 24 h) exerts an inhibitory effect on the proliferation of BEAS-2B cells and induces cell cycle arrest [2]. In V79 cells and mouse lymphoma L5178Y tk+/− cells (MLC), Alternariol (10 μM, 24 h) can induce mutations in the HPRT and TK genes [3].
In vivo	Alternariol was administered via intravenous injection (1-5 mg/kg, once daily for 4 consecutive days), demonstrating embryotoxicity and immunotoxicity in mice during embryonic and infant developmental stages, while also triggering apoptosis [4]. In a DMBA-induced breast cancer mouse model, Alternariol (50-200 mg/kg, orally administered once daily for 24 weeks) significantly suppressed breast cancer progression by inducing apoptosis and inhibiting cell proliferation [5].

Chemical Properties

Molecular Weight	258.23
Formula	C₁₄H₁₀O₅
Cas No.	641-38-3
Smiles	O=C1OC2=CC(O)=CC(=C2C=3C=C(O)C=C(O)C13)C
Relative Density.	1.563g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (77.45 mM), Sonication is recommeded.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8725 mL	19.3626 mL	38.7252 mL	193.6258 mL
5 mM	0.7745 mL	3.8725 mL	7.7450 mL	38.7252 mL
10 mM	0.3873 mL	1.9363 mL	3.8725 mL	19.3626 mL
20 mM	0.1936 mL	0.9681 mL	1.9363 mL	9.6813 mL
50 mM	0.0775 mL	0.3873 mL	0.7745 mL	3.8725 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

Alternariol

Related Tags: Alternariol chemical structure | Alternariol in vivo | Alternariol in vitro | Alternariol formula | Alternariol molecular weight