Tamanho : 1g
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Synonyms: Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride
| Description | Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes. |
| Targets & IC50 | pancreatic:4.9 mM, Neuroblastoma:5.4 mM, Hypo19/7:12.5 µM |
| In vitro | METHODS: SK-N-BE cells (neuroblastoma cells) and Panc-1 cells (pancreatic cancer cells) were treated with Thiamine hydrochloride (10-5-102 mM) for 5 days, and the cell growth inhibition was detected by crystal violet assay. RESULTS: Thiamine hydrochloride inhibited the growth of SK-N-BE cells (IC50=4.9 mM) and Panc-1 cells (IC50=5.4 mM). [1] |
| In vivo | METHODS: To investigate the effect of Thiamine hydrochloride on memory, Thiamine hydrochloride (300 µg/kg) was administered to adult mice with scopolamine-induced memory dysfunction every other day for the last 14 days of the experiment. RESULTS: Thiamine hydrochloride improved memory dysfunction in mice through Nrf-2/TLR4 signaling pathway. [2] METHODS: To study the anti-inflammatory and anti-hyperalgesia effects of Thiamine hydrochloride, Thiamine hydrochloride (150-200 mg/kg) was administered intraperitoneally to Wistar rats with adjuvant-induced arthritis for 21 days. RESULTS: Thiamine hydrochloride showed anti-inflammatory and anti-hyperalgesia effects. [3] METHODS: To study the anti-inflammatory activity of Thiamine hydrochloride, Thiamine hydrochloride (20 mg/kg) was administered intraperitoneally to rats with colitis for 5 days. RESULTS: Thiamine hydrochloride attenuated macroscopic parameters and the summary colitis index in colitis rats. [4] |
| Synonyms | Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride |
| Molecular Weight | 337.27 |
| Formula | C12H18Cl2N4OS |
| Cas No. | 67-03-8 |
| Smiles | [Cl-].Cl.OCCC=1SC=[N+](C1C)CC2=CN=C(N=C2N)C |
| Relative Density. | 1.401 g/cm3 |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 95 mg/mL (281.67 mM), Sonication is recommended.  DMSO: 3.37 mg/mL (9.99 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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