UNC569 [1350547-65-7]
Referência NB-64-10862-1mL
Tamanho : 1mLx10mM(inDMSO)
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UNC569
(Synonyms: UNC 569) Copy Product InfoSynonyms: UNC 569
Catalog No. T21302 Copy Product Info
Purity: 99.67%
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.
Cas No. 1350547-65-7
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Purity:99.67%
Appearance:Solid
Color:White
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Product Information
UNC569 AI Summary
UNC569 exhibits potent bioactivity as an inhibitor of specific kinases and receptors, notably inhibiting Mer, Axl, and Tyro3 kinases with IC50 values of 2.9 nM, 37.0 nM, and 48.0 nM respectively, and a Ki value of 4.3 nM for Mer inhibition. It also demonstrates inhibitory effects on FLT3, MAPKAPK2, Ret, and Ret Y791F mutant kinases at 10 times their IC50 concentrations and inhibits Mer autophosphorylation with an IC50 of 141.0 nM in human 697 cells. Pharmacokinetic properties of the compound include a volume of distribution at steady state of 5.83 L.kg-1, a clearance rate of 19.5 mL.min-1.kg-1, and oral bioavailability of 57.0%..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors. |
| Targets & IC50 | Axl:37 nM(IC50), Mer:4.3 nM(Ki), Mer:2.9 nM(IC50) |
| Synonyms | UNC 569 |
| Molecular Weight | 396.5 |
| Formula | C22H29FN6 |
| Cas No. | 1350547-65-7 |
| Smiles | CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2.15 mg/mL (5.42 mM), Sonication is recommended.  H2O: Insoluble | |||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Saline: 0.22 mg/mL (0.55 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.52 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||