Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

Oxytocin [50-56-6]

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Referência NB-64-29460-500mg

Tamanho : 500mg

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Oxytocin

(Synonyms: α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone) Copy Product Info

Synonyms: α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone

Catalog No. T5026 Copy Product Info

Purity: 99.87%

Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering.

Cas No. 50-56-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

Product Information

Oxytocin AI Summary

Oxytocin exhibits a variety of bioactivities, including high binding affinity to the oxytocin receptor (OTR) and vasopressin receptors in different tissues. It acts as an oxytocin receptor antagonist in rat uterine strips both in vitro and in vivo, showing uterotonic activity with varying potency in the presence and absence of Mg2+, and displaying milk ejection activity. The compound demonstrates vasopressor activity and antidiuretic activity in rat models, affecting urinary volume, and electrolyte excretion. It has an EC50 of 0.4 nM for the oxytocin receptor in human cells and shows a preference for the vasopressin V1a receptor with an EC50 of 0.08 nM compared to higher values for the V2 receptor. Oxytocin also shows agonist activity at human vasopressin and oxytocin receptors, affecting intracellular calcium levels in assays. It demonstrates stability in gastric fluid but lower stability in intestinal fluid, indicating potential challenges in oral bioavailability. Additionally, it exhibits good pharmacokinetic properties such as high binding affinity and short half-life in different species, with no significant adverse effects on liver cells. The compound's multifunctional profile, including potent agonist and antagonist activities, makes it a candidate for further exploration in modulating hormonal pathways related to oxytocin and vasopressin receptors..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering.
Targets & IC50	CHO cells:24.5 nM (EC50), CHO-K1 cells:2.3 nM (EC50), COS-1 cells:15 nM (EC50)
In vitro	METHODS: KGN, MA-10 and C18-4 cells were treated with Tris(2,4-di-tert-butylphenyl)phosphate (0.1-100 µM) for 48 h. Cell counts were measured by Hoechst 33342 stained. RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate was not cytotoxic to any of the 3 cell lines. [1]
In vivo	METHODS: To assay acute anti-inflammatory activity in vivo, Tris(2,4-di-tert-butylphenyl)phosphate (50-70 mg/kg, 0.1% sodium carboxymethyl cellulose in 1M phosphate buffer pH 7.2) was administered to a carrageenan-induced rat foot-plantar edema model. RESULTS: Tris(2,4-di-tert-butylphenyl)phosphate at the doses of 50 mg/kg and 70 mg/kg showed significant anti-inflammatory activity in the carrageenan-induced foot-plantar edema model. Tris(2,4-di-tert-butylphenyl)phosphate significantly reduced the volume of raw paw edema. [2]
Synonyms	α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone

Chemical Properties

Molecular Weight	1007.19
Formula	C₄₃H₆₆N₁₂O₁₂S₂
Cas No.	50-56-6
Smiles	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
Relative Density.	1.27 g/cm3

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight,Store at low temperature, Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (99.29 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9929 mL	4.9643 mL	9.9286 mL	49.6431 mL
5 mM	0.1986 mL	0.9929 mL	1.9857 mL	9.9286 mL
10 mM	0.0993 mL	0.4964 mL	0.9929 mL	4.9643 mL
20 mM	0.0496 mL	0.2482 mL	0.4964 mL	2.4822 mL
50 mM	0.0199 mL	0.0993 mL	0.1986 mL	0.9929 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.