Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

GSK-3484862 [2170136-65-7]

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Referência NB-64-02759-5mg

Tamanho : 5mg

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Telefone : +1 850 650 7790

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Contactar o distribuidor local :

Telefone : +1 850 650 7790

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GSK-3484862

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Synonyms:

Catalog No. T11469 Copy Product Info

Purity: 99.96%

GSK-3484862 is a non-covalent Dnmt1 inhibitor that induces DNA hypomethylation, offering potential therapeutic benefits against cancer.

Cas No. 2170136-65-7

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White to Yellow

Product Information

Bioactivity

Description	GSK-3484862 is a non-covalent Dnmt1 inhibitor that induces DNA hypomethylation, offering potential therapeutic benefits against cancer.

Chemical Properties

Molecular Weight	365.45
Formula	C₁₉H₁₉N₅OS
Cas No.	2170136-65-7
Smiles	CCc1c(C#N)c(S[C@@H](C(N)=O)c2ccccc2)nc(N(C)C)c1C#N
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (61.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7364 mL	13.6818 mL	27.3635 mL	136.8176 mL
5 mM	0.5473 mL	2.7364 mL	5.4727 mL	27.3635 mL
10 mM	0.2736 mL	1.3682 mL	2.7364 mL	13.6818 mL
20 mM	0.1368 mL	0.6841 mL	1.3682 mL	6.8409 mL
50 mM	0.0547 mL	0.2736 mL	0.5473 mL	2.7364 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

therapiesmethyltransferase1InhibitorinhibithypomethylationGSK-3484862GSK3484862GSK 3484862epigeneticDNMTsDnmt1DNAMethyltransferaseDNA MTasesDNA MethyltransferaseDNA5-Azacytidine