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Sucrose [57-50-1]

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Referência NB-64-28981-500mg

Tamanho : 500mg

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Sucrose

(Synonyms: D(+)-Sucrose, D-(+)-Saccharose) Copy Product Info

Synonyms: D(+)-Sucrose, D-(+)-Saccharose

Catalog No. T4733 Copy Product Info

Purity: 99.97%

Sucrose (D-(+)-Saccharose) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons.

Cas No. 57-50-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White

Product Introduction

Sucrose AI Summary

Sucrose is highly hydrophilic, with a partition coefficient (logP) of -3.67, and exhibits various bioactivities. It shows moderate binding to human serum albumin (Log B/F = -2.886) and strong binding to guinea pig atrial homogenate (Log B/F = -4.0). The compound also demonstrates low permeability across human Caco-2 cells (logPapp = -5.77) and human skin (log value = -8.87), as well as low capillary permeability in rat brain (Pc = 1.2E-7 cm s-1). In terms of antimicrobial activity, Sucrose exhibits antibacterial effects against Bacillus subtilis ATCC 6633 and Escherichia coli ATCC 25922 with MIC values greater than 20.0 μg after 48 hours. It also shows broad-spectrum activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Escherichia coli with an MIC of 50.0 μg after 24 hours. Sensory evaluations highlight the compound's significant sweetness at a concentration of 100000 ppm, equivalent to 10% sucrose, with no noticeable bitterness or impact on other sensory properties. The sweetness declines rapidly, with a half-life (T1/2) of 0.004028 hours. Despite its various bioactivities, Sucrose shows no significant binding to human CA9 and CA2 and does not exhibit significant inhibition of LPS-induced nitric oxide production in mouse BV2 cells. It does, however, display cytotoxic effects on several human cancer cell lines, with an IC50 greater than 30000 nM. Additionally, antiviral testing against SARS-CoV-2 reveals limited inhibitive effects, with an inhibition percentage of 14.39% at 20 μM concentration in a SARS-CoV-2 3CL-Pro protease assay, and an IC50 greater than 20000 nM in VERO-6 cells. Overall, the multifaceted bioactivities of Sucrose indicate its potential interactions with biological systems, despite some low-affinity interactions in specific assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sucrose (D-(+)-Saccharose) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons.
Synonyms	D(+)-Sucrose, D-(+)-Saccharose

Chemical Properties

Molecular Weight	342.30
Formula	C₁₂H₂₂O₁₁
Cas No.	57-50-1
Smiles	O([C@]1(CO)O[C@H](CO)[C@@H](O)[C@@H]1O)[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Relative Density.	1.5805 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (759.57 mM), Sonication is recommended.

H2O: 100 mg/mL (292.14 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9214 mL	14.6071 mL	29.2141 mL	146.0707 mL
5 mM	0.5843 mL	2.9214 mL	5.8428 mL	29.2141 mL
10 mM	0.2921 mL	1.4607 mL	2.9214 mL	14.6071 mL
20 mM	0.1461 mL	0.7304 mL	1.4607 mL	7.3035 mL
50 mM	0.0584 mL	0.2921 mL	0.5843 mL	2.9214 mL
100 mM	0.0292 mL	0.1461 mL	0.2921 mL	1.4607 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Sucroseobesitymonosaccharidemetabolic diseaseInhibitorinhibitglucosefructoseEndogenousMetaboliteEndogenous MetaboliteDSucroseD-Saccharosedisaccharidediet on preferencediabete

Related Tags: Sucrose chemical structure | Sucrose formula | Sucrose molecular weight