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Sarcosine [107-97-1]

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Referência NB-64-37630-5g

Tamanho : 5g

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Sarcosine

(Synonyms: Sarcosinic acid, Sarcosin, N-methylglycine, N-Methylaminoacetic acid, Methylglycine, Methylaminoacetic acid) Copy Product Info

Synonyms: Sarcosinic acid, Sarcosin, N-methylglycine, N-Methylaminoacetic acid, Methylglycine, Methylaminoacetic acid

Catalog No. T6975 Copy Product Info

Purity: 99.90%

Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

Cas No. 107-97-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.90%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
In vitro	Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist[1]. The viability of the sarcosine-treated cells is significantly reduced[4].
In vivo	Sarcosine has weak anticonvulsant properties[2]. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice[3].
Synonyms	Sarcosinic acid, Sarcosin, N-methylglycine, N-Methylaminoacetic acid, Methylglycine, Methylaminoacetic acid
Cell Research	Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)

Chemical Properties

Molecular Weight	89.09
Formula	C₃H₇NO₂
Cas No.	107-97-1
Smiles	CNCC(O)=O
Relative Density.	1.093 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 250 mg/mL (2806.15 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	11.2246 mL	56.1230 mL	112.2460 mL	561.2302 mL
5 mM	2.2449 mL	11.2246 mL	22.4492 mL	112.2460 mL
10 mM	1.1225 mL	5.6123 mL	11.2246 mL	56.1230 mL
20 mM	0.5612 mL	2.8062 mL	5.6123 mL	28.0615 mL
50 mM	0.2245 mL	1.1225 mL	2.2449 mL	11.2246 mL
100 mM	0.1122 mL	0.5612 mL	1.1225 mL	5.6123 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

schizophreniaSarcosineN-methyl-D-aspartateInhibitorinhibitGlyT1GlyTGlycine transportersEndogenousMetaboliteEndogenous Metabolitedysfunctiondepressioncognitive

Related Tags: Sarcosine chemical structure | Sarcosine in vivo | Sarcosine in vitro | Sarcosine formula | Sarcosine molecular weight