Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

Nootkatone [4674-50-4]

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Referência NB-64-27323-100mg

Tamanho : 100mg

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Nootkatone

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Synonyms:

Catalog No. T3S0195 Copy Product Info

Purity: 99.4%

1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.

Cas No. 4674-50-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.4%

Color:White

Product Introduction

Nootkatone AI Summary

Nootkatone exhibits a range of bioactivities across different biological systems. It effectively inhibits cell degranulation in rat RBL2H3 cells and demonstrates significant inhibition of LPS-induced nitric oxide (NO) production in ddY mouse macrophages, with an IC50 value of 34000.0 nM. Additionally, it has antiproliferative effects against human A549 and HL60 cells, with ID50 values of 58.4 µg/ml and 4.27 µg/ml, respectively. The compound also shows activity against human liver transporters, significantly inhibiting OATP2B1 and slightly inhibiting OATP1B3, while stimulating OATP1B1. In terms of insect repellency, it is effective against Coptotermes formosanus at a concentration of 12.5 µg/g up to 24 hours, and it exhibits cytotoxicity against mouse BV2 cells with a maximum non-toxic concentration of 0.1 µM. Furthermore, Nootkatone acts as an antagonist at human TRPV1 and ORAI1 receptors at 90 µM, impacting capsaicin-induced inward currents. It also inhibits CYP2C19 enzyme activity, showing 70.0% inhibition at 1 µM and 21.9% inhibition at 10 µM concentrations relative to control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.

Chemical Properties

Molecular Weight	218.335
Formula	C₁₅H₂₂O
Cas No.	4674-50-4
Smiles	O=C1C=C2CC[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)C1
Relative Density.	0.997

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250.00 mg/mL (1145.03 mM), Sonication is recommended.

Ethanol: Slightly soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (9.16 mM), Sonication is recommended.

10% DMSO+90% Saline: 10.00 mg/mL (45.80 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5801 mL	22.9006 mL	45.8012 mL	229.0059 mL
5 mM	0.9160 mL	4.5801 mL	9.1602 mL	45.8012 mL
10 mM	0.4580 mL	2.2901 mL	4.5801 mL	22.9006 mL
20 mM	0.2290 mL	1.1450 mL	2.2901 mL	11.4503 mL
50 mM	0.0916 mL	0.4580 mL	0.9160 mL	4.5801 mL
100 mM	0.0458 mL	0.2290 mL	0.4580 mL	2.2901 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

NootkatoneneuroprotectiveInhibitorinhibitimpairmentdiseasecognitiveAMPKAlzheimer's(+)-Nootkatone

Related Tags: Nootkatone chemical structure | Nootkatone formula | Nootkatone molecular weight