Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

Neurodazine [937807-66-4]

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Referência NB-64-07363-1mL

Tamanho : 1mLx10mM(inDMSO)

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Neurodazine

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Synonyms:

Catalog No. T16287 Copy Product Info

Purity: 98.03%

Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt and Shh signaling.

Cas No. 937807-66-4

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.03%

Appearance:Solid

Color:Yellow

Product Information

Bioactivity

Description	Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt and Shh signaling.
In vitro	Treatment with Neurodazine (5 μM; 1-10 d) induces the expression of neuron-specific markers in P19 cells[2]. Neurodazine selectively suppresses astrocyte differentiation of P19 cells[2].

Chemical Properties

Molecular Weight	456.92
Formula	C₂₇H₂₁ClN₂O₃
Cas No.	937807-66-4
Smiles	COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1ccc(o1)-c1cccc(Cl)c1
Relative Density.	1.252 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (547.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (21.89 mM), Suspension.

10% DMSO+90% Saline: < 10 mg/mL (21.89 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1886 mL	10.9428 mL	21.8857 mL	109.4283 mL
5 mM	0.4377 mL	2.1886 mL	4.3771 mL	21.8857 mL
10 mM	0.2189 mL	1.0943 mL	2.1886 mL	10.9428 mL
20 mM	0.1094 mL	0.5471 mL	1.0943 mL	5.4714 mL
50 mM	0.0438 mL	0.2189 mL	0.4377 mL	2.1886 mL
100 mM	0.0219 mL	0.1094 mL	0.2189 mL	1.0943 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

βcateninWnt/β-cateninWnt/betacateninWnt/b-cateninWntNeurodazinebeta-cateninbetacateninbcatenin