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nerolidol [7212-44-4]

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Referência NB-64-18977-10g

Tamanho : 10g

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nerolidol

(Synonyms: Peruviol, (±)-Nerolidol) Copy Product Info

Synonyms: Peruviol, (±)-Nerolidol

Catalog No. T2S2172 Copy Product Info

Purity: 98.41%

Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presence of oxidative lesions.

Cas No. 7212-44-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.41%

Product Introduction

nerolidol AI Summary

nerolidol has bioactivities related to cell viability and nuclear area decrease in various cell lines as evidenced by the IC50 values obtained from different assays. The compound shows significant activity in inhibiting cell viability with an IC50 value of 10,000 nM in a VEGF-stimulated ADSC/ECFC co-culture nuclear area decrease assay. Additionally, in most other cell viability assays, the IC50 values are around 20,000 nM, indicating moderate inhibitory activity toward the viability of these cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presence of oxidative lesions.
Synonyms	Peruviol, (±)-Nerolidol

Chemical Properties

Molecular Weight	222.37
Formula	C₁₅H₂₆O
Cas No.	7212-44-4
Smiles	CC(C)=CCCC(C)=CCCC(C)(O)C=C
Relative Density.	0.88 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1124.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.99 mM), Sonication is recommended.

10% DMSO+90% Saline: 10 mg/mL (44.97 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4970 mL	22.4850 mL	44.9701 mL	224.8505 mL
5 mM	0.8994 mL	4.4970 mL	8.9940 mL	44.9701 mL
10 mM	0.4497 mL	2.2485 mL	4.4970 mL	22.4850 mL
20 mM	0.2249 mL	1.1243 mL	2.2485 mL	11.2425 mL
50 mM	0.0899 mL	0.4497 mL	0.8994 mL	4.4970 mL
100 mM	0.0450 mL	0.2249 mL	0.4497 mL	2.2485 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

ParasitenerolidolInhibitorinhibitFungalEndogenousMetaboliteEndogenous MetaboliteBacterial

Related Tags: nerolidol chemical structure | nerolidol formula | nerolidol molecular weight