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N-Methylsarcosine [1118-68-9]

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Referência NB-64-28325-1g

Tamanho : 1g

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N-Methylsarcosine

(Synonyms: N,N-Dimethylglycine, N,N-Dimethylaminoacetic acid, DMG, Dimethylglycine) Copy Product Info

Synonyms: N,N-Dimethylglycine, N,N-Dimethylaminoacetic acid, DMG, Dimethylglycine

Catalog No. T4120 Copy Product Info

Purity: 98.17%

N-Methylsarcosine (Dimethylglycine) is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role in the development of glycine-based ionic liquids and emulsifiers.

Cas No. 1118-68-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.17%

Product Introduction

N-Methylsarcosine AI Summary

N-Methylsarcosine exhibits antiviral activity against SARS-CoV-2. Its bioactivity was evaluated by determining its capacity to inhibit SARS-CoV-2-induced cytotoxicity in VERO-6 cells. The compound demonstrated an IC50 value greater than 20,000 nM, as assessed through high content imaging analysis after a 48-hour exposure to the virus at 0.01 MOI..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Methylsarcosine (Dimethylglycine) is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role in the development of glycine-based ionic liquids and emulsifiers.
Synonyms	N,N-Dimethylglycine, N,N-Dimethylaminoacetic acid, DMG, Dimethylglycine

Chemical Properties

Molecular Weight	103.12
Formula	C₄H₉NO₂
Cas No.	1118-68-9
Smiles	C(C(O)=O)N(C)C
Relative Density.	1 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (2424.36 mM)

DMSO: 3 mg/mL (29.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	9.6974 mL	48.4872 mL	96.9744 mL	484.8720 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL	96.9744 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL	48.4872 mL
20 mM	0.4849 mL	2.4244 mL	4.8487 mL	24.2436 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.1939 mL	0.9697 mL	1.9395 mL	9.6974 mL
100 mM	0.0970 mL	0.4849 mL	0.9697 mL	4.8487 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

N-MethylsarcosineNMethylsarcosineN MethylsarcosineEndogenousMetaboliteEndogenous Metabolite

Related Tags: N-Methylsarcosine chemical structure | N-Methylsarcosine formula | N-Methylsarcosine molecular weight