Hydroxyethyl cellulose [9004-62-0]

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Hydroxyethyl cellulose

(Synonyms: Cellulose hydroxyethyl ether, 2-Hydroxyethyl cellulose) Copy Product Info

Synonyms: Cellulose hydroxyethyl ether, 2-Hydroxyethyl cellulose

Catalog No. T19362 Copy Product Info
Hydroxyethyl cellulose (2-Hydroxyethyl cellulose) is a nonionic water-soluble modified cellulose polymer used as a thickener in water-soluble cosmetics and personal care formulations.
Cas No. 9004-62-0
For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Hydroxyethyl cellulose (2-Hydroxyethyl cellulose) is a nonionic water-soluble modified cellulose polymer used as a thickener in water-soluble cosmetics and personal care formulations.
In vitro
Hydroxyethyl cellulose demonstrates outstanding cryoprotective effects on lactate dehydrogenase (LDH) during freeze-thaw cycles and significant lyoprotective effects throughout the freeze-drying process. The annealing process minimally affects its stabilizing capabilities. However, the lengthy reconstitution times for hydroxyethyl cellulose lyophilisates are significantly reduced by adding the surfactant Tween 80 before freeze-drying. Furthermore, hydroxyethyl cellulose is utilized to stabilize graphene oxide in physiological solutions, enhancing its suitability for targeted drug delivery. It effectively stabilizes graphene oxide in electrolyte solutions, with the stabilization mechanism being influenced by the hydroxyethyl cellulose content. This content is crucial in tailoring the nanohybrid for specific applications, whether for controlled drug release or folate-targeted drug delivery.
SynonymsCellulose hydroxyethyl ether, 2-Hydroxyethyl cellulose
Chemical Properties
Cas No.9004-62-0
Relative Density.0.6g/mLat 25°C(lit.)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 14.5 mg/mL, Sonication is recommended.
DMSO: 1 mg/mL (insoluble or slightly soluble)

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitHydroxyethyl cellulose
Related Tags: Hydroxyethyl cellulose chemical structure | Hydroxyethyl cellulose in vitro