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D-(+)-Trehalose [99-20-7]

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Referência NB-64-18876-1g

Tamanho : 1g

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D-(+)-Trehalose

(Synonyms: Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous) Copy Product Info

Synonyms: Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous

Catalog No. T2O2798 Copy Product Info

Purity: 99.82%

D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.

Cas No. 99-20-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.82%

Color:White

Product Introduction

D-(+)-Trehalose AI Summary

D-(+)-Trehalose demonstrates a multifaceted bioactivity profile, including potential neuroprotective effects in R6/2 transgenic mice, where it significantly increased the mean survival time to 94.5 days at a 1% oral concentration, albeit with a 25.0% body weight loss after 12 weeks, indicating some toxicity concerns. The compound notably inhibits amyloid beta-40 and amyloid beta (1 to 42) aggregation across various structural forms (unordered, beta-turns, beta-sheets, alpha-helix) and concentrations, as well as reduces amyloid beta-40-induced cell death in C57BL/6 mouse primary cortical neurons. Additionally, D-(+)-Trehalose shows inhibitory activity against various T6PP enzymes from different organisms, with the highest activity against Brugia malayi T6PP. It exhibits antiviral properties against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells, with moderate inhibition of SARS-CoV-2 3CL-Pro protease at 20µM. The compound also demonstrates a binding affinity to Mycobacterium tuberculosis LpqY, with a dissociation constant (Kd) of 36100.0 nM, and shows weak inhibitory activity against human HDAC6. These diverse bioactivities suggest that D-(+)-Trehalose could be a promising candidate for further research and development in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.
Synonyms	Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous

Chemical Properties

Molecular Weight	342.30
Formula	C₁₂H₂₂O₁₁
Cas No.	99-20-7
Smiles	O([C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Relative Density.	1.76 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200 mg/mL (584.28 mM)

DMSO: 247.5 mg/mL (723.05 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9214 mL	14.6071 mL	29.2141 mL	146.0707 mL
5 mM	0.5843 mL	2.9214 mL	5.8428 mL	29.2141 mL
10 mM	0.2921 mL	1.4607 mL	2.9214 mL	14.6071 mL
20 mM	0.1461 mL	0.7304 mL	1.4607 mL	7.3035 mL
50 mM	0.0584 mL	0.2921 mL	0.5843 mL	2.9214 mL
100 mM	0.0292 mL	0.1461 mL	0.2921 mL	1.4607 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

α,α-TrehaloseInhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteD-Trehalose AnhydrousD(+)TrehaloseD (+) Trehalose

Related Tags: D-(+)-Trehalose chemical structure | D-(+)-Trehalose formula | D-(+)-Trehalose molecular weight