General Information
| Short Description | Rabbit polyclonal antibody anti-APH1B (235-257) is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | C.elegans/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.6 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen | Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein. |
| Immunogen Region | 235-257 |
| Specificity | Does not cross react to other component of gamma secretase complex nor with other proteins. |
Additional Info
| Tissue Specificity | Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. |
| Function | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. |
| Protein Name | Gamma-Secretase Subunit Aph-1bAph-1bAph-1betaPresenilin-Stabilization Factor-Like |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gamma-Secretase Subunit Aph-1b antibodyAnti-Aph-1b antibodyAnti-Aph-1beta antibodyAnti-Presenilin-Stabilization Factor-Like antibodyAnti-APH1B antibodyAnti-PSFL antibodyAnti-UNQ688 antibodyAnti-PRO1328 antibody |
Information sourced from Uniprot.org