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(+)-Camphor [464-49-3]

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Referência NB-64-01046-500mg

Tamanho : 500mg

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(+)-Camphor

(Synonyms: D-Camphor, D-(+)-Camphor, (1R)-(+)-Camphor) Copy Product Info

Synonyms: D-Camphor, D-(+)-Camphor, (1R)-(+)-Camphor

Catalog No. T0882 Copy Product Info

Purity: 98.82%

(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.

Cas No. 464-49-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.82%

Appearance:Solid

Color:White

Product Introduction

(+)-Camphor AI Summary

(+)-Camphor exhibits a diverse range of bioactivities and pharmacological properties. It shows binding energy of 11.4 kCal mol-1 and good aqueous solubility with a Log S value of -1.96. The compound displays antioxidant activity with an EC50 of 2400.0 μg/mL and also demonstrates inhibition of COX2 at 100 μM, although with less than 30.0% inhibition. It has antimicrobial activity against Propionibacterium acnes with an MIC of 200.0 μg/mL and inhibits various microbial strains at higher concentrations. (+)-Camphor acts as a TRPA1 channel antagonist with IC50 values for mustard oil and thymol-induced responses at 660,000.0 nM and 400,000.0 nM, respectively, and it also exhibits agonist activity at TRPV3 at 100.0 μM. It shows moderate antifeedant and insecticidal activities against several insect species, including Spodoptera littoralis, Leptinotarsa decemlineata, and Myzus persicae. For example, against the Colorado potato beetle (Leptinotarsa decemlineata), it results in mortality rates up to 93.3% in larval and adult stages. The compound manifests antifungal activity against Rhizoctonia solani with an EC50 of 488.0 μg/mL and interacts with acetylcholinesterase from Electrophorus electricus, displaying a Ki of 50000.0 nM. Additionally, it demonstrates antiviral properties against several viruses, including SARS-CoV-2 and Influenza A, and inhibits viral replication with notable EC50 values. In terms of cytotoxicity, (+)-Camphor affects MDCK cells with a CTD50 of 3289.5 μM and demonstrates liver toxicity markers. It also shows moderate liver toxicity characterized by significantly elevated levels of ALT, AST, and alkaline phosphatase activities. Overall, (+)-Camphor possesses properties of potential pharmacological interest, including bioactivities against inflammatory pathways, antioxidant properties, antimicrobial and antifungal activities, as well as specific insecticidal and antiviral effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
Synonyms	D-Camphor, D-(+)-Camphor, (1R)-(+)-Camphor

Chemical Properties

Molecular Weight	152.23
Formula	C₁₀H₁₆O
Cas No.	464-49-3
Smiles	CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2
Relative Density.	0.99 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 28 mg/mL (183.93 mM), Sonication is recommended.

DMSO: 55 mg/mL (361.3 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5690 mL	32.8450 mL	65.6901 mL	328.4504 mL
5 mM	1.3138 mL	6.5690 mL	13.1380 mL	65.6901 mL
10 mM	0.6569 mL	3.2845 mL	6.5690 mL	32.8450 mL
20 mM	0.3285 mL	1.6423 mL	3.2845 mL	16.4225 mL
50 mM	0.1314 mL	0.6569 mL	1.3138 mL	6.5690 mL
100 mM	0.0657 mL	0.3285 mL	0.6569 mL	3.2845 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

TRPVChannelTRPV3TRPV ChannelTRPChannelTRP ChannelInhibitorinhibitCamphorBacterial(+)-Camphor(+)Camphor(+) Camphor

Related Tags: (+)-Camphor chemical structure | (+)-Camphor formula | (+)-Camphor molecular weight