Size : 5mg
Phone : +1 850 650 7790
Synonyms:
| Description | 21-Deoxycortisol-D8 isol-D8 is a deuterated compound of 21-Deoxycortisol. 21-Deoxycortisol (T36915) has a CAS number of 641-77-0. 21-Deoxycortisol (T36915) is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. |
| Molecular Weight | 354.51 |
| Formula | C21H22D8O4 |
| Cas No. | 2479914-04-8 |
| Smiles | C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C(C3)([2H])[2H])=C(C(=O)C(C4)([2H])[2H])[2H])([C@@H](O)C1)05)05)(CC[C@@]2(C(C([2H])([2H])[2H])=O)O)05 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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