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> H Cadherin Protein, Rat, Recombinant (His)

H Cadherin Protein, Rat, Recombinant (His)

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H Cadherin Protein, Rat, Recombinant (His)

(Synonyms: cadherin 13) Copy Product Info

Synonyms: cadherin 13

Catalog No. TMPY-03798 Copy Product Info
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadherin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.9 kDa and the accession number is A0A096MK38.
Other Forms of H Cadherin Protein, Rat, Recombinant (His):
H Cadherin Protein, Mouse, Recombinant (His)
H Cadherin Protein, Mouse, Recombinant (hFc)
H Cadherin Protein, Rat, Recombinant (hFc)
H Cadherin Protein, Rat, Recombinant
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadherin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.9 kDa and the accession number is A0A096MK38.
Species
Rat
Expression System
HEK293 Cells
TagC-His
Accession NumberQ8R490
ConstructionA DNA sequence encoding the rat CDH13(NP_620244.1)(Met1-Ala692) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 22
Protein Purity
> 95 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonymscadherin 13
Research Background
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.
Chemical Properties
Molecular Weight74.9 kDa (predicted); 117 and 95 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: H Cadherin Protein, Rat, Recombinant (His) chemical structure | H Cadherin Protein, Rat, Recombinant (His) molecular weight