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Gibberellic acid [77-06-5]

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Referentie NB-64-18496-500mg

Formaat : 500mg

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Gibberellic acid

(Synonyms: Gibberellin A3, Gibberellin, GA3) Copy Product Info

Synonyms: Gibberellin A3, Gibberellin, GA3

Catalog No. T2955 Copy Product Info

Purity: 99.85%

Gibberellic acid (GA3) is a hormone found in plants and fungi.

Cas No. 77-06-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.85%

Appearance:Solid

Color:White

Product Introduction

Gibberellic acid AI Summary

Gibberellic acid shows cytotoxicity against human HL60 cells and human BIU87 cells as observed in the MTT assay, with IC50 values greater than 100.0 µg/mL, suggesting limited potency at the tested concentrations. Additionally, the compound exhibits cytotoxic activity against human LNCAP cells, resulting in a reduction in cell viability of less than 30% at a concentration of 10 µM after 72 hours. Moreover, Gibberellic acid demonstrates antiviral activity against SARS-CoV-2 by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an IC50 value greater than 20,000 nM, indicating moderate potency against the virus-induced cytotoxicity at this concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Gibberellic acid (GA3) is a hormone found in plants and fungi.
Synonyms	Gibberellin A3, Gibberellin, GA3

Chemical Properties

Molecular Weight	346.37
Formula	C₁₉H₂₂O₆
Cas No.	77-06-5
Smiles	20[C@@]12CC[C@]3(O)C[C@]1(CC3=C)[C@@H](C(O)=O)[C@]1(20)[C@@]3(C)[C@@H](O)C=C[C@@]21OC3=O
Relative Density.	1.493 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 138 mg/mL (398.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8871 mL	14.4354 mL	28.8709 mL	144.3543 mL
5 mM	0.5774 mL	2.8871 mL	5.7742 mL	28.8709 mL
10 mM	0.2887 mL	1.4435 mL	2.8871 mL	14.4354 mL
20 mM	0.1444 mL	0.7218 mL	1.4435 mL	7.2177 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	2.8871 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4435 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

steroidogenesisInhibitorinhibitGibberellin A-3Gibberellin A 3Gibberellic acidGA-3GA 3

Related Tags: Gibberellic acid chemical structure | Gibberellic acid formula | Gibberellic acid molecular weight