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D-Arabinose [10323-20-3]

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Referentie NB-64-18906-1mL

Formaat : 1mLx10mM(inDMSO)

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D-Arabinose

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Synonyms:

Catalog No. T2S0461 Copy Product Info

Purity: 99.91%

Inexpensive starting material for chiral synthesis.

Cas No. 10323-20-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.91%

Appearance:Solid

Color:White

Product Introduction

D-Arabinose AI Summary

D-Arabinose demonstrates versatile bioactivity across various biological systems. It inhibits Human acrosin, showing 50.0% inhibition with aldopentoses and 36.0% inhibition with aldoses. In rat L6 cells, it increases [3H]2-deoxy-D-glucose uptake by a fold change (FC) of 1.38 when preincubated with 20 mM D-glucose for 24 hours, indicating potential bioactivity in glucose uptake. For Neisseria meningitidis lgtC, D-Arabinose shows an enzyme efficiency with a Kcat/Km ratio of 0.1 /mM/min. Additionally, it inhibits the Menin-MLL interaction in MLL-related leukemias with a potency of 31622.8 nM and also targets GCN5L2 with a potency of 2238.7 nM. In Caenorhabditis elegans N2 L1 larvae, it reduces body size at concentrations of 16 mM and 42 mM, with activity percentages of 15.2% and 7.8% respectively. At 42 mM, it exhibits an IC50 value of 7500000.0 nM under monoxenic conditions, highlighting its potential in inhibiting larval growth..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Inexpensive starting material for chiral synthesis.

Chemical Properties

Molecular Weight	150.13
Formula	C₅H₁₀O₅
Cas No.	10323-20-3
Smiles	[C@@H]([C@@H](CO)O)([C@@H](C=O)O)O
Relative Density.	1.757g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (199.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6609 mL	33.3045 mL	66.6089 mL	333.0447 mL
5 mM	1.3322 mL	6.6609 mL	13.3218 mL	66.6089 mL
10 mM	0.6661 mL	3.3304 mL	6.6609 mL	33.3045 mL
20 mM	0.3330 mL	1.6652 mL	3.3304 mL	16.6522 mL
50 mM	0.1332 mL	0.6661 mL	1.3322 mL	6.6609 mL
100 mM	0.0666 mL	0.3330 mL	0.6661 mL	3.3304 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteD-ArabinoseDArabinoseD Arabinose

Related Tags: D-Arabinose chemical structure | D-Arabinose formula | D-Arabinose molecular weight