Formaat : 2mg
Telefoonnummer : +1 850 650 7790
Synonyms:
| Description | 18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling. |
| In vivo | Administration of 18-oxocortisol in rats triggers mineralocorticoid-type hypertension, characterized by hypokalemia, as well as enlargement of cardiac and renal tissues and cardiovascular lesions. Similarly, when administered to sheep, 18-oxocortisol leads to a swift elevation in blood pressure. Nonetheless, achieving an increase in blood pressure necessitates high doses[3]. |
| Molecular Weight | 376.449 |
| Formula | C21H28O6 |
| Cas No. | 2410-60-8 |
| Smiles | 22[C@@]12CC[C@](O)(C(=O)CO)[C@]1(C[C@H](O)[C@@]1(22)[C@@]2(22)CCC2=CC(=O)CC[C@]12C)C=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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