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Arbutin [497-76-7]

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Referentie NB-64-00652-1mL

Formaat : 1mLx10mM(inDMSO)

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Arbutin

(Synonyms: β-Arbutin, p-Arbutin) Copy Product Info

Synonyms: β-Arbutin, p-Arbutin

Catalog No. T0473 Copy Product Info

Purity: 99.87%

Arbutin (p-Arbutin)(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melanin.

Cas No. 497-76-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

Product Information

Arbutin AI Summary

Arbutin demonstrates significant bioactivity as an inhibitor of tyrosinase, a key enzyme involved in melanin synthesis. It shows varying IC50 values for mushroom tyrosinase inhibition, ranging from 7,300,000 nM to 24,000,000 nM, and also inhibits tyrosinase in mouse B16 cells with IC50 values as low as 30,260.0 nM. This compound is effective against alpha-MSH-stimulated melanogenesis in mouse B16 cells, with an IC50 of 180,000 nM. Additionally, it exhibits antimelanogenic properties, reducing melanin production in Melan-a cells with IC50 values up to 174,000.0 nM. Furthermore, Arbutin also shows antioxidant activity and mild cytotoxicity against various cell lines, indicating its potential for applications in skin-lightening and anti-pigmentation treatments. However, it lacks antimicrobial activity against several bacteria and demonstrates limited antiviral effects against SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Arbutin (p-Arbutin)(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melanin.
Targets & IC50	Tyrosinase:1.09 mM
Synonyms	β-Arbutin, p-Arbutin

Chemical Properties

Molecular Weight	272.25
Formula	C₁₂H₁₆O₇
Cas No.	497-76-7
Smiles	O([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C2=CC=C(O)C=C2
Relative Density.	1.556g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100 mg/mL (367.31 mM), Sonication is recommended.

H2O: 100 mg/mL (367.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.6731 mL	18.3655 mL	36.7309 mL	183.6547 mL
5 mM	0.7346 mL	3.6731 mL	7.3462 mL	36.7309 mL
10 mM	0.3673 mL	1.8365 mL	3.6731 mL	18.3655 mL
20 mM	0.1837 mL	0.9183 mL	1.8365 mL	9.1827 mL
50 mM	0.0735 mL	0.3673 mL	0.7346 mL	3.6731 mL
100 mM	0.0367 mL	0.1837 mL	0.3673 mL	1.8365 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Tyrosinasebeta-Arbutinb-ArbutinArbutin

Related Tags: Arbutin chemical structure | Arbutin formula | Arbutin molecular weight

Arbutin [497-76-7]

Referentie NB-64-00652-1mL

Neem contact op met een lokale distributeur :

Neem contact op met een lokale distributeur :

Arbutin

Product Information

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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