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Amcinonide [51022-69-6]

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Referentie NB-64-00418-25mg

Formaat : 25mg

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Amcinonide

(Synonyms: CL-34699) Copy Product Info

Synonyms: CL-34699

Catalog No. T0261 Copy Product Info

Purity: 99.74%

Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.

Cas No. 51022-69-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.74%

Color:White

Product Introduction

Amcinonide AI Summary

Amcinonide exhibits a diverse range of bioactivities according to various assay data. It shows potent activity in multiple areas, including modulation of miRNAs, activation of miR-21, inhibition of Cruzain, inhibition of neuropeptide S receptor, inhibition of B-Cell Receptor Signaling, inhibition of Histone Lysine Methyltransferase G9a, and inhibition of malarial parasite plastid. Additionally, it inhibits cell surface uPA generation, Lassa and Marburg viruses binding/entry, mutant isocitrate dehydrogenase 1, and Vaccinia Orthopoxvirus, as well as displaying GLP-1 receptor inverse agonism. The compound also induces DNA re-replication in both normal breast and colon cancer cells and synthetic lethality in tumor cells. It exhibits liver-related bioactivity, causing increases in alkaline phosphatase, SGOT, SGPT, LDH, and GGT—key indicators of liver health—though it shows no association with drug-induced liver injuries. Additionally, Amcinonide inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1 transfected CHO cells. Regarding antiviral activity, Amcinonide shows varying results against SARS-CoV-2. It demonstrates potential antiviral activity in Vero E6 cells and HRCE cells; however, the inhibition percentage remains low in certain assays. It posts a bioactivity of 9.76% inhibition of SARS-CoV-2 3CL-Pro protease at a 20µM concentration and inhibits virus-induced cytotoxicity in Vero-6 cells. Nevertheless, it shows no significant inhibition of most targets in the receptor binding assays, suggesting its role as a potential modulator rather than a direct inhibitor across various biological targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
Targets & IC50	NO release:3.38 nM
Synonyms	CL-34699

Chemical Properties

Molecular Weight	502.57
Formula	C₂₈H₃₅FO₇
Cas No.	51022-69-6
Smiles	22[C@@]12C[C@@]3(22)[C@]4(22)CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC1(CCCC1)O2)C(=O)COC(C)=O
Relative Density.	1.33 g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (497.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (19.9 mM), Solution.

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.97 mM), Sonication is recommended.

10% DMSO+90% Saline: < 10 mg/mL (19.9 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9898 mL	9.9489 mL	19.8977 mL	99.4886 mL
5 mM	0.3980 mL	1.9898 mL	3.9795 mL	19.8977 mL
10 mM	0.1990 mL	0.9949 mL	1.9898 mL	9.9489 mL
20 mM	0.0995 mL	0.4974 mL	0.9949 mL	4.9744 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9898 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9949 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitGlucocorticoidReceptorGlucocorticoid ReceptorCL34699CL 34699AnnexinAAnnexin A1Annexin AAmcinonide

Related Tags: Amcinonide chemical structure | Amcinonide formula | Amcinonide molecular weight

Amcinonide [51022-69-6]

Referentie NB-64-00418-25mg

Neem contact op met een lokale distributeur :

Neem contact op met een lokale distributeur :

Amcinonide

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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