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> TNF R1 Protein, Mouse, Recombinant

TNF R1 Protein, Mouse, Recombinant

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TNF R1 Protein, Mouse, Recombinant

(Synonyms: Tumor necrosis factor receptor type I, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tnfrsf1a, Tnfr-1, Tnfr1) Copy Product Info

Synonyms: Tumor necrosis factor receptor type I, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tnfrsf1a, Tnfr-1, Tnfr1

Catalog No. TMPJ-00280 Copy Product Info
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome
Other Forms of TNF R1 Protein, Mouse, Recombinant:
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His)
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (hFc)
TNFR1/CD120a/TNFRSF1A Protein, Rat, Recombinant (His)
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome
Species
Mouse
Expression System
E. coli
TagTag Free
Accession NumberP25118
Amino AcidIle22-Ala212
ConstructionIle22-Ala212
Protein Purity
Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsTumor necrosis factor receptor type I, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tnfrsf1a, Tnfr-1, Tnfr1
Research Background
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome
Chemical Properties
Molecular Weight20-27 KDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageLyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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