Reagentia en instrumenten voor immunologie, celbiologie en moleculaire biologie.

Lutein [127-40-2]

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Referentie NB-64-27395-50mg

Formaat : 50mg

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Telefoonnummer : +1 850 650 7790

Datasheet (EN)

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Lutein

(Synonyms: Xantofyl, Xanthophyll, Vegetable Lutein) Copy Product Info

Synonyms: Xantofyl, Xanthophyll, Vegetable Lutein

Catalog No. T3S1858 Copy Product Info

Purity: 99.01%

1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.

Cas No. 127-40-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.01%

Appearance:Solid

Color:Orange

Product Introduction

Lutein AI Summary

Lutein exhibits a range of notable bioactivities and chemical properties. It is particularly bioactive as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1), with a potency of 26608.6 nM in cells in the absence of CPT, and shows gametocytocidal activity with a potency of 25118.9 nM. The compound demonstrates significant antioxidant activity, inhibiting antimycin-induced mitochondrial ROS production by 89.7% at 10 µM in mouse 661W cells. Additionally, Lutein possesses antiviral activity, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM with an inhibition rate of 17.37%, as well as in VERO-6 cells, though with a slightly lower inhibition rate of -0.03%. It also inhibits the SARS-CoV-2 3CL-Pro protease by 8.322% at a concentration of 20 µM. Chemically, Lutein has a log POW value of 3.89, indicating its lipophilicity and higher affinity for lipid-based substances. The compound's stability and ratios can vary significantly depending on food sources and preparation methods, with the highest ratios found in raw blackberries and raw paprika. Lastly, Lutein shows mild inhibitory activity in enzymatic assays of human HDAC6..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.
Synonyms	Xantofyl, Xanthophyll, Vegetable Lutein

Chemical Properties

Molecular Weight	568.87
Formula	C₄₀H₅₆O₂
Cas No.	127-40-2
Smiles	C(=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=1C(C)(C)C[C@H](O)CC1C)\C)\C)/C)/C)\[C@@H]2C(C)(C)C[C@@H](O)C=C2C
Relative Density.	0.9944 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Keep away from direct sunlight,Store at low temperature,Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10.5 mg/mL (18.46 mM), Sonication is recommended.

H2O: Insoluble

Ethanol: 10 mg/mL (17.58 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7579 mL	8.7894 mL	17.5787 mL	87.8935 mL
5 mM	0.3516 mL	1.7579 mL	3.5157 mL	17.5787 mL
10 mM	0.1758 mL	0.8789 mL	1.7579 mL	8.7894 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

LuteinAntibacterial

Related Tags: Lutein chemical structure | Lutein formula | Lutein molecular weight

Lutein [127-40-2]

Referentie NB-64-27395-50mg

Neem contact op met een lokale distributeur :

Neem contact op met een lokale distributeur :

Lutein

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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