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L-Ornithine [70-26-8]

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Referentie NB-64-00900-200mg

Formaat : 200mg

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L-Ornithine

(Synonyms: (S)-2,5-Diaminopentanoic acid) Copy Product Info

Synonyms: (S)-2,5-Diaminopentanoic acid

Catalog No. T0737 Copy Product Info

Purity: 99.91%

L-Ornithine ((S)-2, 5-diaminopentanoic acid) is a non-protein amino acid. L-Ornithine is mainly used in the urea cycle to remove excess nitrogen from the body. L-Ornithine is renoprotective. L-Ornithine has antifatigue effects.

Cas No. 70-26-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.91%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	L-Ornithine ((S)-2, 5-diaminopentanoic acid) is a non-protein amino acid. L-Ornithine is mainly used in the urea cycle to remove excess nitrogen from the body. L-Ornithine is renoprotective. L-Ornithine has antifatigue effects.
Targets & IC50	Arginase (bovine):1.02 mM (Ki)
In vitro	METHODS: HK-2 cells were treated with L-Ornithine (100, 300 μM) for 24 hours, and ROS levels were measured using fluorescence microscopy. RESULTS: Ornithine protected HK-2 cells from ROS production. [1]
In vivo	METHODS: To investigate the effect of L-Ornithine on peripheral clock gene expression, mice were orally treated with L-Ornithine (1000 mg/kg) for 3 days. RESULTS: The phase of PER2 gene expression in liver, submandibular gland and kidney was significantly advanced in L-Ornithine treated mice. [2] METHODS: To investigate the effect of L-Ornithine on sleep behavior, L-Ornithine was added to the diet of maternal mice, and its effect on the sleep behavior of offspring mice was observed. RESULTS: L-Ornithine supplementation increased sleep-like behavior in mice. [3] METHODS: To study the effect of L-Ornithine on acute necrotizing pancreatitis, rats were intraperitoneally injected with L-Ornithine (3 g/kg). RESULTS: Severe acute necrotizing pancreatitis was induced by L-Ornithine in rats. [4]
Synonyms	(S)-2,5-Diaminopentanoic acid

Chemical Properties

Molecular Weight	132.16
Formula	C₅H₁₂N₂O₂
Cas No.	70-26-8
Smiles	NCCC[C@H](N)C(O)=O
Relative Density.	1.165 g/cm3

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 50 mg/mL (378.33 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.5666 mL	37.8329 mL	75.6659 mL	378.3293 mL
5 mM	1.5133 mL	7.5666 mL	15.1332 mL	75.6659 mL
10 mM	0.7567 mL	3.7833 mL	7.5666 mL	37.8329 mL
20 mM	0.3783 mL	1.8916 mL	3.7833 mL	18.9165 mL
50 mM	0.1513 mL	0.7567 mL	1.5133 mL	7.5666 mL
100 mM	0.0757 mL	0.3783 mL	0.7567 mL	3.7833 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Ornithine decarboxylase antizyme 1Ornithine carbamoyltransferaseOrnithine aminotransferaseL-OrnithineLOrnithineL OrnithineInhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteArginase-2Arginase-1AminoAcidsandDerivativesAmino Acids and Derivatives2,5-Diaminopentanoic acid

Related Tags: L-Ornithine chemical structure | L-Ornithine in vivo | L-Ornithine in vitro | L-Ornithine formula | L-Ornithine molecular weight