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Aucubin [479-98-1]

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Referentie NB-64-22034-10mg

Formaat : 10mg

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Aucubin

(Synonyms: Rhinanthin, Aucuboside) Copy Product Info

Synonyms: Rhinanthin, Aucuboside

Catalog No. T3416 Copy Product Info

Purity: 99.83%

Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Cas No. 479-98-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.83%

Color:White

Product Introduction

Aucubin AI Summary

Aucubin exhibits a range of bioactivities, including inhibiting the classical complement pathway activation at 4 µM with significantly higher inhibition (89.3%) in the presence of beta glucosidase. It demonstrates potent inhibition of L3MBTL1 (63.1 nM) and induces DNA re-replication (183.6 nM) in SW480 colon adenocarcinoma cells. The compound also shows estrogenic activity at the ERalpha in human MVLN cells with activities of 81.25% and 99.1% at concentrations of 100 µg/mL and 20 µg/mL, respectively, compared to E2. It inhibits electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at 2 mg/mL, although the inhibition percentages are modest (-1.28% for AChE and -12.67% for BChE). Additionally, it exhibits moderate to high inhibitory activity against the COX1 enzyme (48.2% to 50.2%) but weaker activity against the COX2 enzyme (below 30%). It shows no significant cytotoxicity against various human cancer cell lines (IC50 > 10000 nM) and demonstrates minimal inhibitory effects against SARS-CoV-2 3CL-Pro protease (0.17% at 20 µM). Lastly, it exhibits 0.14% inhibition of SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
Synonyms	Rhinanthin, Aucuboside

Chemical Properties

Molecular Weight	346.33
Formula	C₁₅H₂₂O₉
Cas No.	479-98-1
Smiles	OCC1OC(OC2OC=CC3C(O)C=C(CO)C23)C(O)C(O)C1O
Relative Density.	1.61 g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (288.74 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8874 mL	14.4371 mL	28.8742 mL	144.3710 mL
5 mM	0.5775 mL	2.8874 mL	5.7748 mL	28.8742 mL
10 mM	0.2887 mL	1.4437 mL	2.8874 mL	14.4371 mL
20 mM	0.1444 mL	0.7219 mL	1.4437 mL	7.2185 mL
50 mM	0.0577 mL	0.2887 mL	0.5775 mL	2.8874 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4437 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

ulmoidesPlantagoosteoprotectiveNF-κBNFκBNF-kBNFkBneuroprotectiveiridoidInhibitorinhibitinflammatoryILReceptorIL-1βIL ReceptorhepatoprotectiveglucosideEucommiacancerBacterialAucubinasiaticaantioxidantantimicrobialanti-fibroticaging

Related Tags: Aucubin chemical structure | Aucubin formula | Aucubin molecular weight