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AMPK activator 12 [431920-24-0]

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Referentie NB-64-43167-10mg

Formaat : 10mg

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AMPK activator 12

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Synonyms:

Catalog No. T78791 Copy Product Info

Purity: 99.57%

AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.

Cas No. 431920-24-0

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.57%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.

Chemical Properties

Molecular Weight	426.35
Formula	C₂₃H₂₄BrNO₂
Cas No.	431920-24-0
Smiles	BrC1=CC=C(OCC(O)CN(CC=2C=CC=CC2)CC=3C=CC=CC3)C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (234.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (11.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3455 mL	11.7275 mL	23.4549 mL	117.2745 mL
5 mM	0.4691 mL	2.3455 mL	4.6910 mL	23.4549 mL
10 mM	0.2345 mL	1.1727 mL	2.3455 mL	11.7275 mL
20 mM	0.1173 mL	0.5864 mL	1.1727 mL	5.8637 mL
50 mM	0.0469 mL	0.2345 mL	0.4691 mL	2.3455 mL
100 mM	0.0235 mL	0.1173 mL	0.2345 mL	1.1727 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

AMPK

Related Tags: AMPK activator 12 chemical structure | AMPK activator 12 formula | AMPK activator 12 molecular weight