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1-Monomyristin [589-68-4]

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Referentie NB-64-29088-100mg

Formaat : 100mg

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1-Monomyristin

(Synonyms: rac-Glycerol 1-myristate, Monomyristin, Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate) Copy Product Info

Synonyms: rac-Glycerol 1-myristate, Monomyristin, Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate

Catalog No. T4859 Copy Product Info

Purity: 99.58%

1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial strains. 1-Myristoyl-rac-glycerol is used in colloidal chemistry as a nonionic surfactant in the development of micelles.

Cas No. 589-68-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.58%

Appearance:Solid

Color:White

Product Introduction

1-Monomyristin AI Summary

1-Monomyristin exhibits significant biological activity, showing toxicity against brine shrimp with an LC50 of 53.3 µg/mL. Additionally, it demonstrates cytotoxic effects against various human cancer cell lines: A498 cells, PC3 cells, and MIAPaCa2 cells, with ED50 values of 3.58 µg/mL, 8.84 µg/mL, and 1.87 µg/mL, respectively, after 7 days, as determined by MTT assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial strains. 1-Myristoyl-rac-glycerol is used in colloidal chemistry as a nonionic surfactant in the development of micelles.
Synonyms	rac-Glycerol 1-myristate, Monomyristin, Glyceryl myristate, 2,3-Dihydroxypropyl tetradecanoate

Chemical Properties

Molecular Weight	302.45
Formula	C₁₇H₃₄O₄
Cas No.	589-68-4
Smiles	CCCCCCCCCCCCCC(=O)OCC(O)CO
Relative Density.	0.9748 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble), Sonication is recommended.

DMSO: 50 mg/mL (165.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3063 mL	16.5317 mL	33.0633 mL	165.3166 mL
5 mM	0.6613 mL	3.3063 mL	6.6127 mL	33.0633 mL
10 mM	0.3306 mL	1.6532 mL	3.3063 mL	16.5317 mL
20 mM	0.1653 mL	0.8266 mL	1.6532 mL	8.2658 mL
50 mM	0.0661 mL	0.3306 mL	0.6613 mL	3.3063 mL
100 mM	0.0331 mL	0.1653 mL	0.3306 mL	1.6532 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitFungalFatty acid amide hydrolaseFAAHEndogenousMetaboliteEndogenous MetaboliteBacterialAutophagy1-Monomyristin1Monomyristin1 Monomyristin

Related Tags: 1-Monomyristin chemical structure | 1-Monomyristin formula | 1-Monomyristin molecular weight