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(-)-α-Pinene [7785-26-4]

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Referentie NB-64-61970-1g

Formaat : 1g

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(-)-α-Pinene

(Synonyms: (1S)-(-)-Alpha-Pinene) Copy Product Info

Synonyms: (1S)-(-)-Alpha-Pinene

Catalog No. TN1202 Copy Product Info

Purity: 98.60%

(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.

Cas No. 7785-26-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.60%

Appearance:Liquid

Color:Transparent

Product Introduction

Bioactivity

Description	(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.
In vitro	(1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons[1]. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model[1].
Synonyms	(1S)-(-)-Alpha-Pinene

Chemical Properties

Molecular Weight	136.23
Formula	C₁₀H₁₆
Cas No.	7785-26-4
Smiles	CC1(C)[C@]2(C[C@@]1(CC=C2C)19)19
Relative Density.	0.874 g/cm3 at 25℃

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (367.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (7.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3405 mL	36.7026 mL	73.4053 mL	367.0264 mL
5 mM	1.4681 mL	7.3405 mL	14.6811 mL	73.4053 mL
10 mM	0.7341 mL	3.6703 mL	7.3405 mL	36.7026 mL
20 mM	0.3670 mL	1.8351 mL	3.6703 mL	18.3513 mL
50 mM	0.1468 mL	0.7341 mL	1.4681 mL	7.3405 mL
100 mM	0.0734 mL	0.3670 mL	0.7341 mL	3.6703 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

γ-Aminobutyric acid Receptorα-PineneVirusProteaseVirus ProteaseInhibitorinhibitHuman Endogenous MetaboliteGamma-aminobutyric acid ReceptorGABAReceptorGABAAGABA ReceptorEndogenousMetaboliteEndogenous MetaboliteBacteriala-PineneAlpha-Pinene()αPinene( ) α Pinene

Related Tags: (-)-α-Pinene chemical structure | (-)-α-Pinene in vitro | (-)-α-Pinene formula | (-)-α-Pinene molecular weight