Prazosin [19216-56-9]
Cat# NB-64-11665-25mg
Size : 25mg
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Prazosin
(Synonyms: Prazosine, Prazocin, Furazosin) Copy Product InfoSynonyms: Prazosine, Prazocin, Furazosin
Catalog No. T22406 Copy Product Info
Purity: 99.89%
Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.
Cas No. 19216-56-9
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.89%
Appearance:Solid
Color:White
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Product Information
Prazosin AI Summary
Prazosin exhibits strong alpha-1 adrenergic receptor antagonism with a very high binding affinity, demonstrated by Ki values ranging from 0.19 nM to 0.32 nM across different assays. It shows a significantly lower affinity for the alpha-2 adrenergic receptor, with Ki values up to 4830.0 nM. This compound is highly selective for alpha-1 receptors over alpha-2 receptors, indicated by a selectivity ratio of around 1258.9. Prazosin effectively reduces blood pressure in spontaneously hypertensive rats, showing dose-dependent antihypertensive activity with a maximum reduction of 45.0 mmHg at an oral dose of 30 mg/kg. It also exhibits significant vasorelaxant activity, blocking norepinephrine-induced contractions in rat and rabbit arterial tissues. Furthermore, Prazosin demonstrates robust antagonist activity in various adrenergic subtypes, notably alpha-1A, alpha-1B, and alpha-1D adrenergic receptors. Along with the cardiovascular functions, it also shows potential in modulating neurotransmitter responses, given its efficacy in displacing radioligands like [3H]prazosin from rat cerebral cortex membranes and displaying antagonist activity at the dopamine D2 receptors. Prazosin's effective oral bioavailability and selective inhibition properties make it a promising candidate for addressing cardiovascular conditions such as hypertension..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension. |
| Synonyms | Prazosine, Prazocin, Furazosin |
| Molecular Weight | 383.4 |
| Formula | C19H21N5O4 |
| Cas No. | 19216-56-9 |
| Smiles | NC=1C2=C(N=C(N1)N3CCN(C(=O)C4=CC=CO4)CC3)C=C(OC)C(OC)=C2 |
| Relative Density. | 1.352g/cm3 |
| Storage | Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (130.41 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.04 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||