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Anti-Notch 2 Polyclonal Antibody

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Cat# NB-64-159505-200uL

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Anti-Notch 2 Polyclonal Antibody

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Synonyms:

Catalog No. TMAB-09569 Copy Product Info
Anti-Notch 2 Polyclonal Antibody is a Rabbit antibody targeting Notch 2. Anti-Notch 2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-Notch 2 Polyclonal Antibody is a Rabbit antibody targeting Notch 2. Anti-Notch 2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Pig,Rabbit)
Verified Activity
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Notch 2) Polyclonal Antibody, Unconjugated (TMAB-09569) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining.
Application
IHC-P
IHC-Fr
IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane; Single-pass type I membrane protein. Notch 2 intracellular domain: Nucleus.
Tissue SpecificityExpressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Notch2
Antigen Species
Human
Gene Name
NOTCH2
Gene ID
4853
Protein Name
Neurogenic locus notch homolog protein 2
Uniprot ID
Q04721
Chemical Properties
Molecular WeightTheoretical: 262 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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