Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Lipoic acid [1200-22-2]

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Cat# NB-64-11497-1mL

Size : 1mLx10mM(inDMSO)

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Lipoic acid

(Synonyms: R-(+)-Thioctic acid, (R)-(+)-α-Lipoic acid, (R)-(+)-1,2-Dithiolane-3-pentanoic acid) Copy Product Info

Synonyms: R-(+)-Thioctic acid, (R)-(+)-α-Lipoic acid, (R)-(+)-1,2-Dithiolane-3-pentanoic acid

Catalog No. T22235 Copy Product Info

Purity: 99.79%

Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.

Cas No. 1200-22-2

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.79%

Appearance:Solid

Color:Yellow

Product Introduction

Lipoic acid AI Summary

Lipoic acid exhibits a variety of bioactivities with significant potential in neuroprotection, cytoprotection, anti-inflammatory, and anticancer responses. It shows mild effects on myocardial electrical activity and malondialdehyde accumulation under specific in vitro conditions. The compound demonstrates notable neuroprotective effects by protecting mouse hippocampal neuronal HT-22 cell lines from glutamate-induced oxidative stress and preventing glutathione depletion in mice. It blocks alpha1A, alpha1B, and alpha-1D adrenoceptors and shows antioxidant activity in t-BuOOH treated LNCaP cells. Despite its low inhibition of human acetylcholinesterase and butyrylcholinesterase, it exhibits cytotoxicity towards various human cell lines, including Bel7402 and NCI-H460, and induces apoptosis in these cells. Additionally, Lipoic acid has shown antihyperalgesic activity in rats and cytoprotective activity in H2O2-induced human ECV304 cells, albeit with dose-dependent responses. It inhibits nitrite levels in LPS-induced mouse RAW264.7 cells, indicating anti-inflammatory properties. The compound exhibits potent inhibition of COX-1 and COX-2 enzymes, mitochondrial protective activity, and metal chelating activity. Furthermore, Lipoic acid demonstrates inhibition of TDP-43 binding to RNA and competitive binding to human PXR LBD. In various antioxidant assays, it shows capabilities in scavenging hydroxyl and DPPH radicals, inhibiting peroxynitrite-induced cell death, and reducing ferric ions. It also exhibits antiviral activity against SARS-CoV-2 and affects metal ion-induced oxidative processes. Lipoic acid displays protective and cytotoxic effects in rat cerebral cortex neurons depending on the concentration used. Overall, while its cytotoxicity and pro-oxidant tendencies warrant caution, its diverse biological activities make Lipoic acid a potential candidate for further research in multiple therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
Synonyms	R-(+)-Thioctic acid, (R)-(+)-α-Lipoic acid, (R)-(+)-1,2-Dithiolane-3-pentanoic acid

Chemical Properties

Molecular Weight	206.33
Formula	C₈H₁₄O₂S₂
Cas No.	1200-22-2
Smiles	C(CCCC(O)=O)[C@@H]1CCSS1
Relative Density.	1.218 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242 mg/mL (1172.88 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (24.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8466 mL	24.2330 mL	48.4660 mL	242.3302 mL
5 mM	0.9693 mL	4.8466 mL	9.6932 mL	48.4660 mL
10 mM	0.4847 mL	2.4233 mL	4.8466 mL	24.2330 mL
20 mM	0.2423 mL	1.2117 mL	2.4233 mL	12.1165 mL
50 mM	0.0969 mL	0.4847 mL	0.9693 mL	4.8466 mL
100 mM	0.0485 mL	0.2423 mL	0.4847 mL	2.4233 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

α-Lipoic acidR-Thioctic acidReactiveOxygenSpeciesReactive Oxygen SpeciesMitochondrialMetabolismMitochondrial MetabolismLipoic acidInhibitorinhibitEndogenousMetaboliteEndogenous Metabolitealpha-Lipoic acida-Lipoic acid1,2-Dithiolane-3-pentanoic acid

Related Tags: Lipoic acid chemical structure | Lipoic acid formula | Lipoic acid molecular weight