General Information
| Short Description | RNase H1 Blocking Peptide for STJ506225 is synthetically produced from the 240-286 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen | Synthetic peptide corresponding to amino acids within region 240-286 on human Rnase H1 protein. |
| Immunogen Region | 240-286 |
| Specificity | This blocking peptide is recommended for use in combination with RNase H1 antibody, STJ506225 |
Additional Info
| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II. |
| Peptide Name | Ribonuclease H1Rnase H1Ribonuclease H Type Ii |
| Cellular Localisation | Cytoplasm |
| Alternative Peptide Names | Ribonuclease H1 proteinRnase H1 proteinRibonuclease H Type Ii proteinRNASEH1 proteinRNH1 protein |
Information sourced from Uniprot.org