Size : 50mg
Telefono : +1 850 650 7790
Synonyms: NSC-361456 sodium
| Description | Pyrazine diazohydroxide (NSC 361456) sodium is an antineoplastic agent that forms DNA adducts through reactive pyrazine diazo ions. It is used in research for renal cancer, colorectal cancer, melanoma, and leukemia. |
| In vivo | Pyrazine diazohydroxide (sodium) administered at doses of 44.5-150 mg/kg via intraperitoneal injection on days 12, 16, and 20 exhibits a stronger cytotoxic effect on lung metastatic tumors than on primary tumors in mice with LOX melanoma ascites cell xenografts. |
| Synonyms | NSC-361456 sodium |
| Molecular Weight | 148.1 |
| Formula | C4H5N4NaO |
| Cas No. | 103829-46-5 |
| Smiles | [Na].O=NNC1=NC=CN=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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