Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Lauramine oxide [1643-20-5]

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Cat# NB-64-10605-1g

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Lauramine oxide

(Synonyms: Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide) Copy Product Info

Synonyms: Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide

Catalog No. T20936 Copy Product Info

Purity: 99.71%

Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.

Cas No. 1643-20-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.71%

Appearance:Solid

Color:White

Product Introduction

Lauramine oxide AI Summary

Lauramine oxide is a multifaceted bioactive molecule with significant inhibitory effects against various targets. It notably inhibits Oleoyl-CoA Synthetase (OSC) with an IC50 value of 2150.0 nM and demonstrates an 84.0% inhibitory effect at a concentration of 20 µM, underscoring its potency in this pathway. Additionally, it shows inhibitory activity on anti-DNP-IgE-induced degranulation in rat RBL2H3 cells, with a 40.0% inhibition rate observed at 25 µM after 30 minutes. The compound also interacts with several signaling pathways: it acts as an agonist of the retinoid X receptor alpha and the antioxidant response element (ARE) signaling pathway through Nrf2-dependent transcriptional activity, and an antagonist of androgen and glucocorticoid receptor signaling. Furthermore, it serves as an activator of both rat and human pregnane X receptor (PXR) signaling pathways. Moreover, in assays involving human OSC expressed in Saccharomyces cerevisiae, Lauramine oxide exhibited complete inhibition (100.0%) at 20 µM in one assay, 85.0% inhibition in another, and an IC50 value of 6310.0 nM. These diverse bioactivities highlight its potential as a multi-target therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.
Synonyms	Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide

Chemical Properties

Molecular Weight	229.4
Formula	C₁₄H₃₁NO
Cas No.	1643-20-5
Smiles	C(CCCCCCCCC)CCN(C)(C)=O
Relative Density.	0.996 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.94 mg/mL (34.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 0.79 mg/mL (3.44 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3592 mL	21.7960 mL	43.5920 mL	217.9599 mL
5 mM	0.8718 mL	4.3592 mL	8.7184 mL	43.5920 mL
10 mM	0.4359 mL	2.1796 mL	4.3592 mL	21.7960 mL
20 mM	0.2180 mL	1.0898 mL	2.1796 mL	10.8980 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Lauryldimethylamine OxideLauramine OxideDimethylaurylamine OxideBacterial

Related Tags: Lauramine oxide chemical structure | Lauramine oxide formula | Lauramine oxide molecular weight