Size : 5mg
Telefono : +1 850 650 7790
Synonyms:
| Description | FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that reduces hepatic glucose production and improves insulin sensitivity and glucose regulation in db/db mice, without causing weight gain [1]. |
| In vitro | FOXO1-IN-3 (Compound 10) at 10 μM inhibits cAMP/Dexamethasone-induced mRNA expression of G6pc and Pck1 in primary hepatocytes from normal mice after 6 hours of treatment [1]. |
| In vivo | FOXO1-IN-3 (Compound 10) (16 mg/kg, oral administration, twice daily for 10 days) effectively reduced blood glucose levels in db/db mice [1]. Additionally, it showed synergistic glucose-lowering effects in Streptozotocin-induced diabetic mice with depleted β-cells when combined with FGF21 (0.45 mg/kg) [1]. FOXO1-IN-3 exhibited significant plasma exposure and oral bioavailability in mice at 1 mg/kg intravenously and 10 mg/kg orally, despite a short half-life [1]. |
| Molecular Weight | 401.46 |
| Formula | C22H23N7O |
| Cas No. | 2451093-95-9 |
| Smiles | O=C(NC1=CC(=NN1)C2=NC=3C=CC=CC3N2)C4=CC=C(C=C4)N5CCN(C)CC5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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