Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

DL-Menthol [89-78-1]

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Cat# NB-64-18671-2g

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DL-Menthol

(Synonyms: Hexahydrothymol, 15356-70-4, (±)-Menthol) Copy Product Info

Synonyms: Hexahydrothymol, 15356-70-4, (±)-Menthol

Catalog No. T2979 Copy Product Info

Purity: 99.74%

DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.

Cas No. 89-78-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.74%

Color:White

Product Introduction

DL-Menthol AI Summary

DL-Menthol is a multifaceted molecule demonstrating various bioactivities. It functions as an inhibitor of COX2, showing an inhibition rate of less than 30.0% at 100 μM and 60.0% at 0.1 μg/mL. The compound is active in the expressed human recombinant enzymes UGT1A4 and UGT2A1, with activities recorded at 41.0 pm/min/mg and 32.0 pm/min/mg, respectively. It also exhibits lytic activity against Monographella nivalis var. nivalis MAFF 305031, causing 45.7% hyphal lysis at 0.2 mg/ml after 48 hours. Additionally, DL-Menthol acts as an agonist at TRPM8 in differentiated rat/mouse F11 cells and in human TRPM8 receptors, with EC50 values of 23400.0 nM and 10100.0 nM, respectively. It also activates human TRPA1 receptors with an EC50 of 96000.0 nM. Its agonist activity extends to the N-terminal rat ST3 receptor-fused human TAS2R7 in HEK293T cells, indicating calcium signaling in a concentration-dependent manner up to 2.60 mM. Further bioactivities include inhibition of human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 50.1 nM, and Cav1.2 calcium current in rabbit ventricular myocytes with an IC50 of 74600.0 nM. It acts as an antagonist on human OR5K1 in HEK293 cells, inhibiting the response to 2,6-dimethylpyrazine by at least 50.0% at 100 μM. Despite these activities, DL-Menthol has limited effect on the SARS-CoV-2 3CL-Pro protease and SARS-CoV-2 induced cytotoxicity of VERO-6 cells. The compound shows minimal antiviral activity with an 11.1% inhibition of the 3CL-Pro protease at 20 μM and a -0.18% inhibition of cytotoxicity at 10 μM. Activity assays on human HDAC6 report low inhibition rates of 2.89% and -3.28% depending on the substrate used. Lastly, although tested extensively, the compound displayed no significant activity in assays with AC50 values exceeding 30,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.
Synonyms	Hexahydrothymol, 15356-70-4, (±)-Menthol

Chemical Properties

Molecular Weight	156.27
Formula	C₁₀H₂₀O
Cas No.	89-78-1
Smiles	[C@H](C)(C)[C@H]1[C@H](O)C[C@H](C)CC1
Relative Density.	0.89

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

H2O: Insoluble

DMSO: 245 mg/mL (1567.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3992 mL	31.9959 mL	63.9918 mL	319.9590 mL
5 mM	1.2798 mL	6.3992 mL	12.7984 mL	63.9918 mL
10 mM	0.6399 mL	3.1996 mL	6.3992 mL	31.9959 mL
20 mM	0.3200 mL	1.5998 mL	3.1996 mL	15.9980 mL
50 mM	0.1280 mL	0.6399 mL	1.2798 mL	6.3992 mL
100 mM	0.0640 mL	0.3200 mL	0.6399 mL	3.1996 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

γ-Aminobutyric acid ReceptorRacementholMentholInhibitorinhibitGamma-aminobutyric acid ReceptorGABAReceptorGABA ReceptorDL-MentholDLMentholDL Mentholcholinesterase

Related Tags: DL-Menthol chemical structure | DL-Menthol formula | DL-Menthol molecular weight